Tumor necrosis factor-α blockade ameliorates diabetic nephropathy in rats

Rosmarinic Acid Ameliorates Diabetic Nephropathy in Uninephrectomized Diabetic Rats

Objective(s) Oxidative stress plays an important role in diabetic nephropathy pathogenesis. Rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. Material and Methods Forty male rats were uninephrectomized from the left flank.The rats were divided in four groups randomly; group one as control, group two diabetic untreatment...

Tumor Necrosis Factor-α Blockade and the Risk of Vasculitis

rosmarinic acid ameliorates diabetic nephropathy in uninephrectomized diabetic rats

objective(s) oxidative stress plays an important role in diabetic nephropathy pathogenesis. rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. material and methods forty male rats were uninephrectomized from the left flank.the rats were divided in four groups randomly; group one as control, group two diabetic untreatment, g...

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

OBJECTIVE Cannabinoid receptor 1 (CB1) is localized in the central nervous system and in peripheral tissues involved in energy metabolism control. However, CB1 receptors are also expressed at low level within the glomeruli, and the aim of this study was to investigate their potential relevance in the pathogenesis of proteinuria in experimental type 1 diabetes. RESEARCH DESIGN AND METHODS Stre...

Carvedilol Ameliorates Early Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats

Diabetic nephropathy results in end-stage renal disease. On the other hand, carvedilol has been reported to have various pharmacological properties. The aim of this study therefore is to evaluate the possible protective effect of carvedilol on streptozotocin-induced early diabetic nephropathy and various mechanisms underlie this effect in rats. Single i.p. injection of streptozotocin (65 mg/kg)...